520416

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520416 [2018/11/22 21:16] (current)
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 +====== Antimyoclonic action of clonazepam: the role of serotonin.======
 +
 +** Article date:** 1979/11/23
 +~~META:date created = 1979-11-23~~
 +
 +** PubMed ID: 520416 **
 +
 +** Journal name: European journal of pharmacology (ISSN: 0014-2999) **
 +
 +** ABSTRACT **
 +
 +Clonazepam (5-(2-chlorophenyl)-1,​3-dihydro-7-nitro 2H-1,4 benzodiazepin-2-one) (2 mg/kg) reduced a p,​p'​-DDT-induced myoclonus in mice by 50%. This antimyoclonic action of clonazepam was counteracted by the serotonin (5-HT) receptor blockers methysergide,​ metergoline and cinnanserin and potentiated by the 5-HT uptake inhibitors fluoxetine and chlorimipramine. Clonazepam (4 mg/kg) reduced plasma tryptophan by 27%, but had no effect on brain tryptopham, 5-HT, 5-hydroxyindoleacetic acid, 5-HT synthesis and 3H-5-HT receptor binding. Clonazepam (10(-5) M) inhibited brain synaptosomal 3H-5-HT uptake by 23% and increased 3H-5-HT release by 24%. However, 2-8 mg/kg of clonazepam administered intraperitoneally had no effect on 5-HT uptake or release. gamma-Aminobutyric acid (GABA) agonists (muscimol, acetylenic GABA, amino-oxyacetic acid) and the GABA antagonists bicuculline and isoniazid had no effect on p,​p'​-DDT-induced myoclonus. Furthermore,​ bicuculline did not counteract the antimyoclonic effect of clonazepam. We suggest that the antimyoclonic action of clonazepam is mediated by enhancement of serotonergic rather than GABAergic neurotransmission.
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 +===== ===== 
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 +{{gview 100%,​450px>​ http://​directlinks.cc/​files/​muscimol/​520416.pdf}}
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 +Author List: Chung Hwang E, Van Woert M H
 +
 +Publication Types: Journal Article; Research Support, U.S. Gov't, P.H.S.
 +
 +Substances mentioned in the article: Anticonvulsants;​ Benzodiazepinones;​ Receptors, Serotonin; Serotonin; Hydroxyindoleacetic Acid; Clonazepam; Tryptophan; DDT; 
 +
 +Mesh terms: Animals; Anticonvulsants;​ Benzodiazepinones/​pharmacology;​ Clonazepam/​pharmacology;​ DDT/​pharmacology;​ Hydroxyindoleacetic Acid/​metabolism;​ Male; Mice; Myoclonus/​chemically induced; Rats; Receptors, Serotonin/​metabolism;​ Serotonin/​physiology;​ Synaptosomes/​metabolism;​ Tryptophan/​metabolism; ​
 +
 +{{tag> Tryptophan Benzodiazepinones Anticonvulsants Receptors,​_Serotonin Hydroxyindoleacetic_Acid Clonazepam Serotonin DDT }}
 +
 +{{keywords>​ Tryptophan, Benzodiazepinones,​ Anticonvulsants,​ Receptors, Serotonin, Hydroxyindoleacetic Acid, Clonazepam, Serotonin, DDT}}
 +
  
520416.txt · Last modified: 2018/11/22 21:16 (external edit)