527646

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527646 [2018/11/22 21:16] (current)
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 +====== Paradoxical GABA excitation of nigral dopaminergic cells: indirect mediation through reticulata inhibitory neurons.======
 +
 +** Article date:** 1979/11/16
 +~~META:date created = 1979-11-16~~
 +
 +** PubMed ID: 527646 **
 +
 +** Journal name: European journal of pharmacology (ISSN: 0014-2999) **
 +
 +** ABSTRACT **
 +
 +Biochemical and electrophysiological and electrophysiological studies suggest that GABA agonists increase the activity of dopaminergic neurons in the zona compacta (ZC) of the substantia nigra despite a known GABAergic input to ZC cells. Using single-unit recording techniques we have investigated this "​paradoxical"​ effect. One population of neurons located in the zona reticulata (ZR) of the substantia nigra was found to be 20 times more sensitive to iontophoretically applied GABA than ZC neurons. GABA introduced by means of microiontophoresis into the ZR caused an increase in ZC cell activity while glutamic acid introduced in the same manner produced an inhibition of ZC cells. The latter effect was blocked by low doses of picrotoxin. Muscimol (i.v.) caused a decrease in ZR cell activity at the same dose that caused a parallel increase in ZC cell firing rate. These data suggest that ZC cells receive an inhibitory GABAergic input from ZR cells that are in turn inhibited by low doses of GABA agonists. Such an anatomical arrangement would account for the "​paradoxical"​ excitatory effect of GABA agonists on ZC neuron activity.
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 +===== ===== 
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 +{{gview 100%,​450px>​ http://​directlinks.cc/​files/​muscimol/​527646.pdf}}
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 +Author List: Grace A A, Bunney B S
 +
 +Publication Types: Journal Article; Research Support, U.S. Gov't, P.H.S.
 +
 +Substances mentioned in the article: Glutamates; Muscimol; gamma-Aminobutyric Acid; Dopamine; ​
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 +Mesh terms: Animals; Dopamine/​pharmacology;​ Glutamates/​pharmacology;​ Iontophoresis;​ Male; Muscimol/​pharmacology;​ Neural Inhibition/​drug effects; Neurons/​physiology;​ Rats; Stimulation,​ Chemical; Substantia Nigra/​anatomy & histology; gamma-Aminobutyric Acid/​pharmacology; ​
 +
 +{{tag> gamma-Aminobutyric_Acid Glutamates Muscimol Dopamine }}
 +
 +{{keywords>​ gamma-Aminobutyric Acid, Glutamates, Muscimol, Dopamine}}
 +
  
527646.txt · Last modified: 2018/11/22 21:16 (external edit)