Article date: 1977/10/1
PubMed ID: 562761
Journal name: European journal of pharmacology (ISSN: 0014-2999)
GABA and GABA-related drugs such as muscimol, gamma-hydroxybutyric acid and baclofen injected unilaterally into the substantia nigra of rats elicited contraversive turning. Unilateral injections of picrotoxin and bicuculline produced either ipsi- or contraversive turning depending on the volume of vehicle. I.p. applied haloperidol did not abolish the muscimol-induced turning. This and the direction of rotational behavior suggests that the turning behavior elicited by GABA-related drugs is not mediated by the nigrostriatal dopaminergic tract.
Author List: Olpe H R, Schellenberg H, Koella W P
Publication Types: Journal Article
Substances mentioned in the article: Aminobutyrates; GABA Antagonists; gamma-Aminobutyric Acid;
Mesh terms: Aminobutyrates/pharmacology; Animals; Behavior/drug effects; GABA Antagonists; Humans; Injections; Male; Rats; Stereotyped Behavior/drug effects; Substantia Nigra; gamma-Aminobutyric Acid/administration & dosage;