Rotational behavior induced in rats by intranigral application of GABA-related drugs and GABA antagonists.

Article date: 1977/10/1

PubMed ID: 562761

Journal name: European journal of pharmacology (ISSN: 0014-2999)


GABA and GABA-related drugs such as muscimol, gamma-hydroxybutyric acid and baclofen injected unilaterally into the substantia nigra of rats elicited contraversive turning. Unilateral injections of picrotoxin and bicuculline produced either ipsi- or contraversive turning depending on the volume of vehicle. I.p. applied haloperidol did not abolish the muscimol-induced turning. This and the direction of rotational behavior suggests that the turning behavior elicited by GABA-related drugs is not mediated by the nigrostriatal dopaminergic tract.

This document is available from: http://directlinks.cc/files/muscimol/562761.pdf

Author List: Olpe H R, Schellenberg H, Koella W P

Publication Types: Journal Article

Substances mentioned in the article: Aminobutyrates; GABA Antagonists; gamma-Aminobutyric Acid;

Mesh terms: Aminobutyrates/pharmacology; Animals; Behavior/drug effects; GABA Antagonists; Humans; Injections; Male; Rats; Stereotyped Behavior/drug effects; Substantia Nigra; gamma-Aminobutyric Acid/administration & dosage;

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