562761

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562761 [2018/11/22 21:16] (current)
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 +====== Rotational behavior induced in rats by intranigral application of GABA-related drugs and GABA antagonists.======
 +
 +** Article date:** 1977/10/1
 +~~META:date created = 1977-10-01~~
 +
 +** PubMed ID: 562761 **
 +
 +** Journal name: European journal of pharmacology (ISSN: 0014-2999) **
 +
 +** ABSTRACT **
 +
 +GABA and GABA-related drugs such as muscimol, gamma-hydroxybutyric acid and baclofen injected unilaterally into the substantia nigra of rats elicited contraversive turning. Unilateral injections of picrotoxin and bicuculline produced either ipsi- or contraversive turning depending on the volume of vehicle. I.p. applied haloperidol did not abolish the muscimol-induced turning. This and the direction of rotational behavior suggests that the turning behavior elicited by GABA-related drugs is not mediated by the nigrostriatal dopaminergic tract.
 +
 +===== ===== 
 +
 +{{gview 100%,​450px>​ http://​directlinks.cc/​files/​muscimol/​562761.pdf}}
 +
 +Author List: Olpe H R, Schellenberg H, Koella W P
 +
 +Publication Types: Journal Article
 +
 +Substances mentioned in the article: Aminobutyrates;​ GABA Antagonists;​ gamma-Aminobutyric Acid; 
 +
 +Mesh terms: Aminobutyrates/​pharmacology;​ Animals; Behavior/​drug effects; GABA Antagonists;​ Humans; Injections; Male; Rats; Stereotyped Behavior/​drug effects; Substantia Nigra; gamma-Aminobutyric Acid/​administration & dosage; ​
 +
 +{{tag> GABA_Antagonists Aminobutyrates gamma-Aminobutyric_Acid }}
 +
 +{{keywords>​ GABA Antagonists,​ Aminobutyrates,​ gamma-Aminobutyric Acid}}
 +
  
562761.txt · Last modified: 2018/11/22 21:16 (external edit)