Antagonism by cholinomimetic drugs of the turning induced by intrastriatal pirenzepine in mice.

Article date: 1987/1/1

PubMed ID: 565479

Journal name: Psychopharmacology (ISSN: 0033-3158)


In order to investigate the behavioural effect of selective blockade of M1 muscarinic receptors in the forebrain, and to characterize a new model for the evaluation of muscarinic agonistic activity, the effect of intrastriatally injected pirenzepine was studied in mice. The direct injection of pirenzepine (0.01-1 microgram/mouse) into the right striatum of conscious mice resulted in contralateral turning behaviour. When injected intraperitoneally (IP) 15 min before pirenzepine (1 microgram), the muscarinic receptor agonists arecoline and pilocarpine (0.3-3 mg/kg), oxotremorine (0.003-0.03 mg/kg) and RS 86 (0.03-1 mg/kg) antagonized pirenzepine-induced turning, as did the choline-esterase inhibitor physostigmine (0.01-0.1 mg/kg) and the nootropic drug aniracetam (10-30 mg/kg). Haloperidol (0.03-0.3 mg/kg IP) weakly, but significantly, decreased the effect of pirenzepine, whereas (+/-) sulpiride (3-100 mg/kg) failed to affect it. Finally, (+/-)-amphetamine (0.1-3 mg/kg IP), citalopram (1-30 mg/kg IP) and muscimol (0.03-0.3 mg/kg IP) failed to modify pirenzepine-induced turning when administered prior to intrastriatal pirenzepine. These results suggest an involvement of M1 muscarinic receptors in rotational behaviour, and indicate that pirenzepine-induced turning may represent a new model for studying the central activity of cholinomimetic drugs.

Author List: Worms P, Biziere K

Publication Types: Journal Article

Substances mentioned in the article: Antipsychotic Agents; Parasympathomimetics; Propylamines; Citalopram; Muscimol; Pirenzepine; Dextroamphetamine;

Mesh terms: Animals; Antipsychotic Agents/pharmacology; Behavior, Animal/drug effects; Citalopram; Corpus Striatum; Dextroamphetamine/pharmacology; Drug Interactions; Female; Injections; Mice; Muscimol/pharmacology; Parasympathomimetics/pharmacology; Pirenzepine/administration & dosage; Propylamines/pharmacology;

Citations: - 4404908

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