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565479 [2018/11/20 14:26] (current)
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 +====== Antagonism by cholinomimetic drugs of the turning induced by intrastriatal pirenzepine in mice.======
 +
 +** Article date:** 1987/1/1
 +~~META:date created = 1987-01-01~~
 +
 +** PubMed ID: 565479 **
 +
 +** Journal name: Psychopharmacology (ISSN: 0033-3158) **
 +
 +** ABSTRACT **
 +
 +In order to investigate the behavioural effect of selective blockade of M1 muscarinic receptors in the forebrain, and to characterize a new model for the evaluation of muscarinic agonistic activity, the effect of intrastriatally injected pirenzepine was studied in mice. The direct injection of pirenzepine (0.01-1 microgram/​mouse) into the right striatum of conscious mice resulted in contralateral turning behaviour. When injected intraperitoneally (IP) 15 min before pirenzepine (1 microgram), the muscarinic receptor agonists arecoline and pilocarpine (0.3-3 mg/kg), oxotremorine (0.003-0.03 mg/kg) and RS 86 (0.03-1 mg/kg) antagonized pirenzepine-induced turning, as did the choline-esterase inhibitor physostigmine (0.01-0.1 mg/kg) and the nootropic drug aniracetam (10-30 mg/kg). Haloperidol (0.03-0.3 mg/kg IP) weakly, but significantly,​ decreased the effect of pirenzepine,​ whereas (+/-) sulpiride (3-100 mg/kg) failed to affect it. Finally, (+/​-)-amphetamine (0.1-3 mg/kg IP), citalopram (1-30 mg/kg IP) and muscimol (0.03-0.3 mg/kg IP) failed to modify pirenzepine-induced turning when administered prior to intrastriatal pirenzepine. These results suggest an involvement of M1 muscarinic receptors in rotational behaviour, and indicate that pirenzepine-induced turning may represent a new model for studying the central activity of cholinomimetic drugs.
 +
 +===== ===== 
 +
 +Author List: Worms P, Biziere K
 +
 +Publication Types: Journal Article
 +
 +Substances mentioned in the article: Antipsychotic Agents; Parasympathomimetics;​ Propylamines;​ Citalopram; Muscimol; Pirenzepine;​ Dextroamphetamine; ​
 +
 +Mesh terms: Animals; Antipsychotic Agents/​pharmacology;​ Behavior, Animal/drug effects; Citalopram; Corpus Striatum; Dextroamphetamine/​pharmacology;​ Drug Interactions;​ Female; Injections; Mice; Muscimol/​pharmacology;​ Parasympathomimetics/​pharmacology;​ Pirenzepine/​administration & dosage; Propylamines/​pharmacology; ​
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 +Citations: ​  - //​[[4404908]]//​
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 +  - //​[[565479]]//​
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 +{{tag> Dextroamphetamine Pirenzepine Citalopram Muscimol Propylamines Parasympathomimetics Antipsychotic_Agents }}
 +
 +{{keywords>​ Dextroamphetamine,​ Pirenzepine,​ Citalopram, Muscimol, Propylamines,​ Parasympathomimetics,​ Antipsychotic Agents}}
 +
  
565479.txt · Last modified: 2018/11/20 14:26 (external edit)