571751

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571751 [2018/11/22 21:16] (current)
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 +====== Amphetamine-induced circling behavior in rats: effects of unilateral microinjections of GABA and GABA-related drugs into substantia nigra.======
 +
 +** Article date:** 1979/5/11
 +~~META:date created = 1979-05-11~~
 +
 +** PubMed ID: 571751 **
 +
 +** Journal name: Brain research (ISSN: 0006-8993) **
 +
 +** ABSTRACT **
 +
 +In these experiments,​ the GABA control upon dopaminergic nigrostriatal neurons has been investigated using circling behavior in the rat. Chronically cannulated rats were given D-amphetamine (2 mg/kg i.p.) 45 min before unilateral microinjection (0.2 microliter/​2 min) into the substantia nigra (SN) of GABA, muscimol, chlordiazepoxide (CDP) or bicuculline. Circling behavior was continuously recorded for 165 min using an automated rotometer. (1) Non-microinjected control rats exhibit a '​spontaneous'​ circling behavior after amphetamine. (2) When applied to the SN contralateral to the preferential side of the '​spontaneous'​ rotations, saline enhances contraversive circling; GABA (5 X 10(-5)M), CDP (5 X 10(-5)M) and muscimol (5 x 10(-7)M, 5 X 10(-8)M) counteract this effect and induce (except CDP) light ipsiversive rotations; GABA (10(-2)M) and muscimol (5 x 10(-5)M) further enhance contraversive turning. (3) When applied to the SN ipsilateral to the preferential side of the '​spontaneous'​ rotations, saline has no marked effect on the ipsiversive circling behavior but induces weak contraversive turning; GABA (5 X 10(-5)M), CDP (5 X 10(-5)M) and muscimol (5 x 10(-8)M) enhance the ipsiversive rotations; GABA (10(-2)M) and muscimol (5 x 10(-5)M) transiently decrease the ipsiversive circling; bicuculline (5 x 10(-5)M) induces a vigorous contraversive turning associated with a transient inhibition of the ipsiversive rotations. These results suggest that the activity of the nigral neurons is presumably stimulated by the microinjection itself, by bicuculline and, to a lesser extent, by high concentrations of GABA and muscimol, and inhibited by low concentrations of GABA, muscimol and CDP. These findings could further support the hypotheses of a GABAergic inhibitory control upon DA nigrostriatal pathways and of a GABA-like activity of CDP.
 +
 +===== ===== 
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 +{{gview 100%,​450px>​ http://​directlinks.cc/​files/​muscimol/​571751.pdf}}
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 +Author List: Thiébot M H, Soubrié P
 +
 +Publication Types: Journal Article
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 +Substances mentioned in the article: Muscimol; gamma-Aminobutyric Acid; Chlordiazepoxide;​ Dextroamphetamine;​ Bicuculline; ​
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 +Mesh terms: Animals; Behavior/​drug effects; Bicuculline/​pharmacology;​ Chlordiazepoxide/​pharmacology;​ Dextroamphetamine/​pharmacology;​ Dominance, Cerebral/​drug effects; Humans; Male; Muscimol/​pharmacology;​ Rats; Stereotyped Behavior/​drug effects; Substantia Nigra/drug effects; gamma-Aminobutyric Acid/​pharmacology; ​
 +
 +{{tag> Bicuculline Dextroamphetamine Chlordiazepoxide gamma-Aminobutyric_Acid Muscimol }}
 +
 +{{keywords>​ Bicuculline,​ Dextroamphetamine,​ Chlordiazepoxide,​ gamma-Aminobutyric Acid, Muscimol}}
 +
  
571751.txt · Last modified: 2018/11/22 21:16 (external edit)