Article date: 1978/1/1
PubMed ID: 582545
Journal name: Arzneimittel-Forschung (ISSN: 0004-4172)
Effects of baclofen, 5-aminomethyl-3-hydroxyisoxazol (muscimol) and GABA-cetylester on spontaneous and olfactory bulb-ablation-induced muricidal behaviour in rats was investigated. At doses of 3–10 mg/kg i.p. baclofen inhibited the killer reaction in spontaneous and lesioned rats to the same extent. In contrast, muscimol (0.75–1.5 mg/kg i.p.) and GABA-cetylester (10–50mg/kg i.p.) depressed markedly only the spontaneous muricidal response. These findings suggest a possibility that muscimol and GABA-cetylester exert their inhibitory action through an activation of GABA-neurons localized in the bulbus olfactorius, whereas baclofen appears to affect also neuronal systems outside this nervous structure.
Author List: Delini-Stula A, Vassout A
Publication Types: Journal Article
Substances mentioned in the article: Aminobutyrates; Muscimol; gamma-Aminobutyric Acid; Baclofen;
Mesh terms: Aggression/drug effects; Aminobutyrates/pharmacology; Animals; Baclofen/pharmacology; Humans; Male; Motor Activity/drug effects; Muscimol/pharmacology; Olfactory Bulb/physiology; Rats; gamma-Aminobutyric Acid/analogs & derivatives;