582545

Influence of baclofen and GABA-minetic agents on spontaneous and olfactory-bulb-ablation-induced muricidal behaviour in the rat.

Article date: 1978/1/1

PubMed ID: 582545

Journal name: Arzneimittel-Forschung (ISSN: 0004-4172)

ABSTRACT

Effects of baclofen, 5-aminomethyl-3-hydroxyisoxazol (muscimol) and GABA-cetylester on spontaneous and olfactory bulb-ablation-induced muricidal behaviour in rats was investigated. At doses of 3โ€“10 mg/kg i.p. baclofen inhibited the killer reaction in spontaneous and lesioned rats to the same extent. In contrast, muscimol (0.75โ€“1.5 mg/kg i.p.) and GABA-cetylester (10โ€“50mg/kg i.p.) depressed markedly only the spontaneous muricidal response. These findings suggest a possibility that muscimol and GABA-cetylester exert their inhibitory action through an activation of GABA-neurons localized in the bulbus olfactorius, whereas baclofen appears to affect also neuronal systems outside this nervous structure.

Author List: Delini-Stula A, Vassout A

Publication Types: Journal Article

Substances mentioned in the article: Aminobutyrates; Muscimol; gamma-Aminobutyric Acid; Baclofen;

Mesh terms: Aggression/drug effects; Aminobutyrates/pharmacology; Animals; Baclofen/pharmacology; Humans; Male; Motor Activity/drug effects; Muscimol/pharmacology; Olfactory Bulb/physiology; Rats; gamma-Aminobutyric Acid/analogs & derivatives;

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