582545

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582545 [2018/11/20 14:26] (current)
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 +====== Influence of baclofen and GABA-minetic agents on spontaneous and olfactory-bulb-ablation-induced muricidal behaviour in the rat.======
 +
 +** Article date:** 1978/1/1
 +~~META:date created = 1978-01-01~~
 +
 +** PubMed ID: 582545 **
 +
 +** Journal name: Arzneimittel-Forschung (ISSN: 0004-4172) **
 +
 +** ABSTRACT **
 +
 +Effects of baclofen, 5-aminomethyl-3-hydroxyisoxazol (muscimol) and GABA-cetylester on spontaneous and olfactory bulb-ablation-induced muricidal behaviour in rats was investigated. At doses of 3--10 mg/kg i.p. baclofen inhibited the killer reaction in spontaneous and lesioned rats to the same extent. In contrast, muscimol (0.75--1.5 mg/kg i.p.) and GABA-cetylester (10--50mg/​kg i.p.) depressed markedly only the spontaneous muricidal response. These findings suggest a possibility that muscimol and GABA-cetylester exert their inhibitory action through an activation of GABA-neurons localized in the bulbus olfactorius,​ whereas baclofen appears to affect also neuronal systems outside this nervous structure.
 +
 +===== ===== 
 +
 +Author List: Delini-Stula A, Vassout A
 +
 +Publication Types: Journal Article
 +
 +Substances mentioned in the article: Aminobutyrates;​ Muscimol; gamma-Aminobutyric Acid; Baclofen; ​
 +
 +Mesh terms: Aggression/​drug effects; Aminobutyrates/​pharmacology;​ Animals; Baclofen/​pharmacology;​ Humans; Male; Motor Activity/​drug effects; Muscimol/​pharmacology;​ Olfactory Bulb/​physiology;​ Rats; gamma-Aminobutyric Acid/​analogs & derivatives; ​
 +
 +{{tag> gamma-Aminobutyric_Acid Baclofen Aminobutyrates Muscimol }}
 +
 +{{keywords>​ gamma-Aminobutyric Acid, Baclofen, Aminobutyrates,​ Muscimol}}
 +
  
582545.txt ยท Last modified: 2018/11/20 14:26 (external edit)