648589

Muscimol antagonizes morphine hypermotility without potentiation of analgesia.

Article date: 1978/4/15

PubMed ID: 648589

Journal name: European journal of pharmacology (ISSN: 0014-2999)

ABSTRACT

Muscimol, a very potent and specific GABA agonist, strongly depressed characteristic morphine-induced locomotor activity. Muscimol induced only a very weak increase in the morphine analgesia measured in the hot plate test which perhaps could be a result of a freezing reaction. No effect on morphine analgesia was observed in the wire grid test. These results indicate that GABA differentially influences morphine stimulation and analgesia.

This document is available from: http://directlinks.cc/files/muscimol/648589.pdf

Author List: Christensen A V, Arnt J, Scheel-Krüger J

Publication Types: Journal Article

Substances mentioned in the article: Analgesics; Isoxazoles; Neuromuscular Blocking Agents; Oxazoles; gamma-Aminobutyric Acid; Morphine;

Mesh terms: Analgesia; Analgesics/pharmacology; Animals; Isoxazoles/pharmacology; Male; Mice; Mice, Inbred Strains; Morphine/antagonists & inhibitors; Motor Activity/drug effects; Neuromuscular Blocking Agents/pharmacology; Oxazoles/pharmacology; gamma-Aminobutyric Acid/pharmacology;

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