Article date: 1978/4/15
PubMed ID: 648589
Journal name: European journal of pharmacology (ISSN: 0014-2999)
Muscimol, a very potent and specific GABA agonist, strongly depressed characteristic morphine-induced locomotor activity. Muscimol induced only a very weak increase in the morphine analgesia measured in the hot plate test which perhaps could be a result of a freezing reaction. No effect on morphine analgesia was observed in the wire grid test. These results indicate that GABA differentially influences morphine stimulation and analgesia.
Author List: Christensen A V, Arnt J, Scheel-Krüger J
Publication Types: Journal Article
Substances mentioned in the article: Analgesics; Isoxazoles; Neuromuscular Blocking Agents; Oxazoles; gamma-Aminobutyric Acid; Morphine;
Mesh terms: Analgesia; Analgesics/pharmacology; Animals; Isoxazoles/pharmacology; Male; Mice; Mice, Inbred Strains; Morphine/antagonists & inhibitors; Motor Activity/drug effects; Neuromuscular Blocking Agents/pharmacology; Oxazoles/pharmacology; gamma-Aminobutyric Acid/pharmacology;