648589

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648589 [2018/11/22 21:16] (current)
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 +====== Muscimol antagonizes morphine hypermotility without potentiation of analgesia.======
 +
 +** Article date:** 1978/4/15
 +~~META:date created = 1978-04-15~~
 +
 +** PubMed ID: 648589 **
 +
 +** Journal name: European journal of pharmacology (ISSN: 0014-2999) **
 +
 +** ABSTRACT **
 +
 +Muscimol, a very potent and specific GABA agonist, strongly depressed characteristic morphine-induced locomotor activity. Muscimol induced only a very weak increase in the morphine analgesia measured in the hot plate test which perhaps could be a result of a freezing reaction. No effect on morphine analgesia was observed in the wire grid test. These results indicate that GABA differentially influences morphine stimulation and analgesia.
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 +===== ===== 
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 +{{gview 100%,​450px>​ http://​directlinks.cc/​files/​muscimol/​648589.pdf}}
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 +Author List: Christensen A V, Arnt J, Scheel-Krüger J
 +
 +Publication Types: Journal Article
 +
 +Substances mentioned in the article: Analgesics; Isoxazoles; Neuromuscular Blocking Agents; Oxazoles; gamma-Aminobutyric Acid; Morphine; ​
 +
 +Mesh terms: Analgesia; Analgesics/​pharmacology;​ Animals; Isoxazoles/​pharmacology;​ Male; Mice; Mice, Inbred Strains; Morphine/​antagonists & inhibitors; Motor Activity/​drug effects; Neuromuscular Blocking Agents/​pharmacology;​ Oxazoles/​pharmacology;​ gamma-Aminobutyric Acid/​pharmacology; ​
 +
 +{{tag> Neuromuscular_Blocking_Agents Morphine gamma-Aminobutyric_Acid Analgesics Oxazoles Isoxazoles }}
 +
 +{{keywords>​ Neuromuscular Blocking Agents, Morphine, gamma-Aminobutyric Acid, Analgesics, Oxazoles, Isoxazoles}}
 +
  
648589.txt · Last modified: 2018/11/22 21:16 (external edit)