686171

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686171 [2018/11/20 14:26] (current)
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 +====== Studies on the role of serotonin receptor subtypes in the effect of sibutramine in various feeding paradigms in rats.======
 +
 +** Article date:** 1999/8/24
 +~~META:date created = 1999-08-24~~
 +
 +** PubMed ID: 686171 **
 +
 +** Journal name: British journal of pharmacology (ISSN: 0007-1188) **
 +
 +** ABSTRACT **
 +
 +The effect of the 5-hydroxytryptamine (5-HT) and noradrenaline (NA) reuptake inhibitor sibutramine was studied in food deprived, neuropeptide Y (NPY)- or muscimol-injected rats. Sibutramine dose-dependently reduced feeding caused by food-deprivation (ED50 = 5.1+/-0.8 mg kg(-1)) or by NPY injection into the paraventricular nucleus of the hypothalamus (ED50 = 6.0+/-0.5 mg kg(-1)). The increase in food intake caused by muscimol injected into the dorsal raphe was not modified by sibutramine (1-10 mg kg(-1)). The hypophagic effect of 5.1 mg kg(-1) sibutramine in food-deprived rats was studied in rats pretreated with different serotonin receptor antagonists. Metergoline (non-selective,​ 0.3 and 1.0 mg kg(-1)), ritanserin (5-HT2A/2C, 0.5 and 1.0 mg kg(-1)) and GR127935 (5-HT1B/​1D),​ 0.5 and 1.0 mg kg(-1)) did not modify the hypophagic effect of sibutramine,​ while SB206553 (5-HT2B/2C, 5 and 10 mg kg(-1)) slightly but significantly reduced it (Fint(2.53) = 3.4; P<0.05). The reduction in food intake caused by 6.0 mg kg(-1) sibutramine in NPY-injected rats was not modified by GR127935 (1.0 mg kg(-1)). The results suggest that, with the possible exception of a partial involvement of 5-HT2B/2C receptors in sibutramine'​s hypophagia in food-deprived rats, 5-HT1 and 5-HT2 receptor subtypes do not play an important role in the hypophagic effect of sibutramine,​ at least in the first 2 h after injection.
 +
 +===== ===== 
 +
 +Author List: Grignaschi G, Fanelli E, Scagnol I, Samanin R
 +
 +Publication Types: Journal Article; Research Support, Non-U.S. Gov't
 +
 +Substances mentioned in the article: Appetite Depressants;​ Cyclobutanes;​ Neuropeptide Y; Oxadiazoles;​ Piperazines;​ Receptors, Serotonin; GR 127935; sibutramine; ​
 +
 +Mesh terms: Animals; Appetite Depressants/​pharmacology;​ Cyclobutanes/​pharmacology;​ Dose-Response Relationship,​ Drug; Eating/drug effects; Male; Neuropeptide Y/​pharmacology;​ Oxadiazoles/​pharmacology;​ Piperazines/​pharmacology;​ Rats; Rats, Sprague-Dawley;​ Receptors, Serotonin/​classification; ​
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 +Citations: ​  - //​[[185540]]//​
 +  - //​[[9756397]]//​
 +  - //​[[6653654]]//​
 +  - //​[[3856458]]//​
 +  - //​[[3826420]]//​
 +  - //​[[2955189]]//​
 +  - //​[[3290473]]//​
 +  - //​[[2541365]]//​
 +  - //​[[2566947]]//​
 +  - //​[[2498930]]//​
 +  - //​[[2315431]]//​
 +  - //​[[1601071]]//​
 +  - //​[[1515949]]//​
 +  - //​[[8413837]]//​
 +  - //​[[7768274]]//​
 +  - //​[[8684598]]//​
 +  - //​[[8720874]]//​
 +  - //​[[8821530]]//​
 +  - //​[[9114726]]//​
 +  - //​[[9144661]]//​
 +  - //​[[9283694]]//​
 +  - //​[[9283714]]//​
 +  - //​[[686171]]//​
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 +{{tag> Neuropeptide_Y GR_127935 Receptors,​_Serotonin Appetite_Depressants Cyclobutanes Oxadiazoles sibutramine Piperazines }}
 +
 +{{keywords>​ Neuropeptide Y, GR 127935, Receptors, Serotonin, Appetite Depressants,​ Cyclobutanes,​ Oxadiazoles,​ sibutramine,​ Piperazines}}
 +
  
686171.txt · Last modified: 2018/11/20 14:26 (external edit)