Influence of GABA receptor agonists and antagonists on the binding of 3H-diazepam to the benzodiazepine receptor.

Article date: 1978/11/1

PubMed ID: 720385

Journal name: European journal of pharmacology (ISSN: 0014-2999)


The GABA receptor agonists, GABA and muscimol, increased, while the GABA receptor antagonist, (+)-bicuculline, decreased the affinity of the benzodiazepine receptor for 3H-diazepam. The effect was seen at both 0 and 25 degrees C in spite of a large difference of affinity for 3H-diazepam at the two temperatures.

This document is available from: http://directlinks.cc/files/muscimol/720385.pdf

Author List: Briley M S, Langer S Z

Publication Types: Journal Article

Substances mentioned in the article: GABA Antagonists; Receptors, Drug; Benzodiazepines; Muscimol; gamma-Aminobutyric Acid; Diazepam; Bicuculline;

Mesh terms: Animals; Benzodiazepines/metabolism; Bicuculline/pharmacology; Brain/metabolism; Diazepam/metabolism; GABA Antagonists; In Vitro Techniques; Muscimol/pharmacology; Rats; Receptors, Drug/metabolism; gamma-Aminobutyric Acid/metabolism;

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