The effects of mammillary body lesions on delayed matching and delayed non-matching to place tasks in the mice.

Article date: 1995/4/1

PubMed ID: 7619304

Journal name: Behavioural brain research (ISSN: 0166-4328)


This study was designed to investigate the effects of different recognition procedures on memory performance in Balb/c mice. To this end, mice were submitted to spontaneous or contingently reinforced delayed non-matching (DNMTP) and delayed matching (DMTP) to place tasks in a T-maze. Results indicate that mammillary bodies (MM)-lesioned subjects are significantly impaired in the DNMTP tasks at the long (6 h) but not the short (5 min) delays; in contrast, they did not exhibit deficits in the DMTP task, whatever the delay considered. We stress the importance of task difficulty as a major factor explaining the different effects of the lesion in the two tasks.

This document is available from: http://directlinks.cc/files/muscimol/7619304.pdf

Author List: Béracochéa D J, Jaffard R

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Ibotenic Acid;

Mesh terms: Animals; Conditioning, Operant/physiology; Food; Ibotenic Acid/toxicity; Male; Mammillary Bodies/anatomy & histology; Memory/physiology; Mice; Mice, Inbred BALB C; Reinforcement (Psychology); Reward; Space Perception/physiology;

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