839217

Biphasic effects of direct, but not indirect, GABA mimetics and antagonists on haloperidol-induced catalepsy.

Article date: 1980/3/1

PubMed ID: 839217

Journal name: Naunyn-Schmiedeberg's archives of pharmacology (ISSN: 0028-1298)

ABSTRACT

At very low doses the GABA agonists SL 76002 and muscimol diminish haloperidol-induced catalepsy. At somewhat higher doses these compounds potentiate catalepsy. Biphasic effects on DA-receptor mediated functions have previously been noted with bicuculline and picrotoxinin. In contrast, manipulation of GABA levels by enzyme inhibition induced only a monophasic effect on dopamine-mediated behaviour. The potentiation of GABA levels by enzyme inhibition induced only a monophasic effect on dopamine-mediated behaviour. The potentiation of haloperidol-induced catalepsy by GABA mimetics is also observed with dipropylacetate, delta-aminovaleric acid and gamma-acetylenic GABA. This GABA-mimetic potentiation of catakepsy was blocked by the coadministration of bicuculline. These results confirm and extend the hypothesis that GABA-neurons influence DA neuron function. Furthermore they suggest that more than one group of GABA receptors influence directly and/or indirectly DA neuronal function, with different resultant effects.

Author List: Worms P, Lloyd K G

Publication Types: Journal Article

Substances mentioned in the article: GABA Antagonists; Allylglycine; Muscimol; gamma-Aminobutyric Acid; Haloperidol; Apomorphine;

Mesh terms: Allylglycine/pharmacology; Animals; Apomorphine/pharmacology; Behavior, Animal/drug effects; Catalepsy/chemically induced; Drug Interactions; GABA Antagonists; Haloperidol/pharmacology; Humans; Male; Muscimol/pharmacology; Rats; Stereotyped Behavior/drug effects; gamma-Aminobutyric Acid/physiology;

Citations: - 923642

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