839217

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839217 [2018/11/20 14:26] (current)
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 +====== Biphasic effects of direct, but not indirect, GABA mimetics and antagonists on haloperidol-induced catalepsy.======
 +
 +** Article date:** 1980/3/1
 +~~META:date created = 1980-03-01~~
 +
 +** PubMed ID: 839217 **
 +
 +** Journal name: Naunyn-Schmiedeberg'​s archives of pharmacology (ISSN: 0028-1298) **
 +
 +** ABSTRACT **
 +
 +At very low doses the GABA agonists SL 76002 and muscimol diminish haloperidol-induced catalepsy. At somewhat higher doses these compounds potentiate catalepsy. Biphasic effects on DA-receptor mediated functions have previously been noted with bicuculline and picrotoxinin. In contrast, manipulation of GABA levels by enzyme inhibition induced only a monophasic effect on dopamine-mediated behaviour. The potentiation of GABA levels by enzyme inhibition induced only a monophasic effect on dopamine-mediated behaviour. The potentiation of haloperidol-induced catalepsy by GABA mimetics is also observed with dipropylacetate,​ delta-aminovaleric acid and gamma-acetylenic GABA. This GABA-mimetic potentiation of catakepsy was blocked by the coadministration of bicuculline. These results confirm and extend the hypothesis that GABA-neurons influence DA neuron function. Furthermore they suggest that more than one group of GABA receptors influence directly and/or indirectly DA neuronal function, with different resultant effects.
 +
 +===== ===== 
 +
 +Author List: Worms P, Lloyd K G
 +
 +Publication Types: Journal Article
 +
 +Substances mentioned in the article: GABA Antagonists;​ Allylglycine;​ Muscimol; gamma-Aminobutyric Acid; Haloperidol;​ Apomorphine; ​
 +
 +Mesh terms: Allylglycine/​pharmacology;​ Animals; Apomorphine/​pharmacology;​ Behavior, Animal/drug effects; Catalepsy/​chemically induced; Drug Interactions;​ GABA Antagonists;​ Haloperidol/​pharmacology;​ Humans; Male; Muscimol/​pharmacology;​ Rats; Stereotyped Behavior/​drug effects; gamma-Aminobutyric Acid/​physiology; ​
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 +Citations: ​  - //​[[923642]]//​
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 +{{tag> GABA_Antagonists gamma-Aminobutyric_Acid Muscimol Allylglycine Haloperidol Apomorphine }}
 +
 +{{keywords>​ GABA Antagonists,​ gamma-Aminobutyric Acid, Muscimol, Allylglycine,​ Haloperidol,​ Apomorphine}}
 +
  
839217.txt ยท Last modified: 2018/11/20 14:26 (external edit)