895876

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

895876 [2018/11/20 14:26] (current)
Line 1: Line 1:
 +====== GABAergic and glycinergic mechanisms within the substantia nigra: pharmacological specificity of dopamine-independent contralateral turning behavior and interactions with other neurotransmitters.======
 +
 +** Article date:** 1979/4/25
 +~~META:date created = 1979-04-25~~
 +
 +** PubMed ID: 895876 **
 +
 +** Journal name: Psychopharmacology (ISSN: 0033-3158) **
 +
 +** ABSTRACT **
 +
 +The pharmacological specificity of the GABA agonist muscimol-induced contralateral turning behavior after unilateral injection into substantia nigra pars reticulata (SNR) has been studied. Muscimol-induced turning was antagonized by intranigral bicuculline methochloride (BMC) and picrotoxin, whereas antagonists of glycine, morphine, dopamine, noradrenaline,​ and serotonin were ineffective. Glycine induced a qualitatively similar turning behavior which was strychnine-sensitive but relatively BMC and picrotoxin-insensitive. Other drugs, including substance P, kainic acid, clonidine, oxymetazoline,​ serotonin, and carbachol, induced turning that could be dissociated from the effect of muscimol. Muscimol-induced turning was dopamine-independent,​ indicated by resistance to haloperidol (1 mg/kg), to pretreatment with reserpine (7.5 mg/kg) plus alpha-methyl-p-tyrosine (200 mg/kg), to haloperidol injections into the SNR, striatum and nucleus accumbens, and finally to kainic acid lesions of the striatum. 6-Hydroxydopamine lesions increased the efficacy of intranigral muscimol, while kainic acid lesions of the SNR antagonized muscimol. Muscimol-induced turning was inhibited by oxotremorine (0.25 mg/kg), by intranigral carbachol, and by apomorphine (0.1--0.5 mg/kg), but only moderately by intranigrally injected apomorphine. These data suggest specificity of GABA-agonist-induced contralateral turning and indicate an interaction between nigral GABA and other neurotransmitters,​ particularly dopamine and acetylcholine.
 +
 +===== ===== 
 +
 +Author List: Arnt J, Scheel-Krüger J
 +
 +Publication Types: Journal Article
 +
 +Substances mentioned in the article: Hydroxydopamines;​ Neurotransmitter Agents; Muscimol; gamma-Aminobutyric Acid; Kainic Acid; Glycine; Dopamine; ​
 +
 +Mesh terms: Animals; Behavior/​drug effects; Dopamine/​metabolism;​ Glycine/​physiology;​ Humans; Hydroxydopamines/​pharmacology;​ Kainic Acid/​pharmacology;​ Male; Muscimol/​pharmacology;​ Neurotransmitter Agents/​physiology;​ Rats; Stereotyped Behavior/​drug effects; Substantia Nigra/​anatomy & histology; Time Factors; gamma-Aminobutyric Acid/​physiology; ​
 +
 +Citations: ​  - //​[[1248538]]//​
 +  - //​[[1252667]]//​
 +  - //​[[1268746]]//​
 +  - //​[[861742]]//​
 +  - //​[[1206397]]//​
 +  - //​[[199852]]//​
 +  - //​[[15087]]//​
 +  - //​[[560304]]//​
 +  - //​[[1000302]]//​
 +  - //​[[551130]]//​
 +  - //​[[4821421]]//​
 +  - //​[[1148841]]//​
 +  - //​[[340238]]//​
 +  - //​[[630396]]//​
 +  - //​[[566207]]//​
 +  - //​[[922480]]//​
 +  - //​[[214805]]//​
 +  - //​[[3629]]//​
 +  - //​[[569589]]//​
 +  - //​[[6745]]//​
 +  - //​[[652058]]//​
 +  - //​[[4827861]]//​
 +  - //​[[4558749]]//​
 +  - //​[[4356204]]//​
 +  - //​[[5559257]]//​
 +  - //​[[25608]]//​
 +  - //​[[414259]]//​
 +  - //​[[562761]]//​
 +  - //​[[775231]]//​
 +  - //​[[22389]]//​
 +  - //​[[976315]]//​
 +  - //​[[639856]]//​
 +  - //​[[37300]]//​
 +  - //​[[834284]]//​
 +  - //​[[20542]]//​
 +  - //​[[566206]]//​
 +  - //​[[620681]]//​
 +  - //​[[17159]]//​
 +  - //​[[890495]]//​
 +  - //​[[16686]]//​
 +  - //​[[8637]]//​
 +  - //​[[561844]]//​
 +  - //​[[19556189]]//​
 +  - //​[[197423]]//​
 +  - //​[[895876]]//​
 +
 +{{tag> gamma-Aminobutyric_Acid Hydroxydopamines Muscimol Kainic_Acid Dopamine Glycine Neurotransmitter_Agents }}
 +
 +{{keywords>​ gamma-Aminobutyric Acid, Hydroxydopamines,​ Muscimol, Kainic Acid, Dopamine, Glycine, Neurotransmitter Agents}}
 +
  
895876.txt · Last modified: 2018/11/20 14:26 (external edit)