985568

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985568 [2018/11/20 14:26] (current)
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 +====== Discovery of antidepressant activity by forced swimming test may depend on pre-exposure of rats to a stressful situation.======
 +
 +** Article date:** 1989/1/1
 +~~META:date created = 1989-01-01~~
 +
 +** PubMed ID: 985568 **
 +
 +** Journal name: Psychopharmacology (ISSN: 0033-3158) **
 +
 +** ABSTRACT **
 +
 +Antidepressant-induced anti-immobility effects have been assessed in animals exposed or not to a pretest session using the forced swimming test. Desipramine,​ maprotiline,​ mianserine (15 and 30 mg/kg), nomifensine (2.5 and 5 mg/kg), d-amphetamine (1 and 2 mg/kg) and muscimol (1 and 2 mg/kg), unlike imipramine (15 and 30 mg/kg), LY-171555 (0.1 and 0.2 mg/kg) and scopolamine (0.5 and 0.1 mg/kg), did not reduce immobility time in rats which had not received the pretest session. On the other hand, all of the drugs tested reduced immobility time in rats exposed to a pretest session. In addition, the degree of antiimmobility effects of desipramine (20 mg/kg) and nomifensine (5 mg/kg) increased proportionally with the level of water (0, 4, 15 and 30 cm) to which animals were exposed at the time of pretest. Furthermore,​ desipramine reduced immobility time in rats pre-exposed to types of stress different from forced swimming, cold, restraint or foot-shock. All drugs were injected intraperitoneally three times, 24, 5 and 1 h before testing. The present findings suggest that a stressful pretest session may reveal pharmacological properties of antidepressants in the forced swimming test. This is also substantiated by the fact that diazepam (2.5 and 5 mg/kg) administered 30 min before the swimming pretest antagonized the anti-immobility effect of 15 mg/kg desipramine.
 +
 +===== ===== 
 +
 +Author List: Borsini F, Lecci A, Sessarego A, Frassine R, Meli A
 +
 +Publication Types: Journal Article; Research Support, Non-U.S. Gov't
 +
 +Substances mentioned in the article: Antidepressive Agents; Ergolines; Quinpirole; Scopolamine Hydrobromide;​ Diazepam; ​
 +
 +Mesh terms: Animals; Antidepressive Agents/​pharmacology;​ Behavior, Animal/drug effects; Diazepam/​pharmacology;​ Dose-Response Relationship,​ Drug; Electroshock;​ Ergolines/​pharmacology;​ Male; Quinpirole; Rats; Restraint, Physical; Scopolamine Hydrobromide/​pharmacology;​ Stress, Psychological/​psychology;​ Swimming; ​
 +
 +Citations: ​  - //​[[6747838]]//​
 +  - //​[[7195816]]//​
 +  - //​[[3695801]]//​
 +  - //​[[6140979]]//​
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 +  - //​[[985568]]//​
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 +{{tag> Antidepressive_Agents Diazepam Quinpirole Scopolamine_Hydrobromide Ergolines }}
 +
 +{{keywords>​ Antidepressive Agents, Diazepam, Quinpirole, Scopolamine Hydrobromide,​ Ergolines}}
 +
  
985568.txt · Last modified: 2018/11/20 14:26 (external edit)